Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,986 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
86-night From The Arctic To Antarctica Cruise
Nuuk to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
9/3/25
|
From
$109,995
|
168-night Navigate the World – Away in Wonder Cruise
Roundtrip Miami |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Mariner
|
Departs
1/7/25
|
From
$107,499
|
154-night The Sense of Adventure: 2026 World Criuise
Roundtrip Miami |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Mariner
|
Departs
1/10/26
|
From
$98,199
|
150-night Away In Wonder: 2025 World Cruise
Miami to San Francisco |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Mariner
|
Departs
1/7/25
|
From
$96,199
|
141-night World of Splendor: 2027 World Cruise
Miami to New York City |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Splendor
|
Departs
1/11/27
|
From
$92,299
|
179-night Viking World Voyage I
Ft. Lauderdale to New York City |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Sky (Ocean)
|
Departs
12/19/24
|
From
$85,995
|
127-night Navigate the World: 2027 World Cruise
Miami to Rome (Civitavecchia) |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Splendor
|
Departs
1/11/27
|
From
$84,299
|
135-night 2026 World Cruise
Los Angeles to Rome (Civitavecchia) |
Cruise Line
Crystal Cruises
|
Cruise Ship
Crystal Serenity
|
Departs
1/11/26
|
From
$84,000
|
162-night Viking World Voyage II
Los Angeles to New York City |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Sky (Ocean)
|
Departs
1/5/25
|
From
$80,995
|
86-night From The Arctic To Antarctica Cruise
Nuuk to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
9/17/26
|
From
$75,995
|
129-Day Ring Of Fire: Hidden Gems Cruise
Los Angeles to Vancouver |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Sojourn
|
Departs
1/6/26
|
From
$75,479
|
22-night Transpacific Cruise
Los Angeles to Papeete |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Shadow
|
Departs
1/4/25
|
From
$75,000
|
123-night World Cruise 2025: Ft. Lauderdale to Barcelona
Ft. Lauderdale to Barcelona |
Cruise Line
Crystal Cruises
|
Cruise Ship
Crystal Serenity
|
Departs
1/7/25
|
From
$66,500
|
197-night World Odyssey Voyage
Los Angeles to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Vista
|
Departs
12/20/25
|
From
$62,999
|
78-night Australia, Asia, and Alaska Cruise
Sydney to Vancouver |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Orion (Ocean)
|
Departs
3/21/25
|
From
$62,895
|
22-night In-Depth Antarctica, Falklands, and South Georgia Expedition
Roundtrip Santiago |
Cruise Line
Hurtigruten
|
Cruise Ship
MS Fram
|
Departs
2/1/25
|
From
$61,478
|
200-night Kaleidoscope of Your World - 2025 World Cruise
Miami to New York City |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
1/5/25
|
From
$60,799
|
196-night Global Horizons - 2025 World Cruise
Roundtrip Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
1/5/25
|
From
$60,799
|
137-night Viking World Cruise
Ft. Lauderdale to London (Greenwich) |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Sky (Ocean)
|
Departs
12/19/24
|
From
$59,995
|
180-night Around the World Voyage
Roundtrip Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Vista
|
Departs
1/6/26
|
From
$57,999
|
120-night Viking World Journeys
Los Angeles to London (Greenwich) |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Sky (Ocean)
|
Departs
1/5/25
|
From
$57,995
|
180-night Around the World in 180 Days - 2025 World Cruise
Miami to San Diego |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
1/5/25
|
From
$54,499
|
70-night Longitudinal World Cruise II
Duluth to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
9/26/24
|
From
$53,495
|
68-night Longitudinal World Cruise V
Buenos Aires to Milwaukee |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
2/20/25
|
From
$52,995
|