Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,912 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
19-night North Pacific Crossing Cruise – Vancouver to Tokyo (Yokohama)
Vancouver to Yokohama (Tokyo) |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Explorer
|
Departs
9/17/25
|
From
$11,399
|
30-night Transpacific Quest Cruise – Vancouver to Tokyo
Vancouver to Tokyo |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Explorer
|
Departs
9/17/25
|
From
$21,699
|
12-night Hawaii Cruise
Vancouver to Honolulu |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Edge
|
Departs
9/19/25
|
From
$2,441
|
22-night Pacific Passage & Jewels Of Japan Cruise
Vancouver to Yokohama (Tokyo) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Quest
|
Departs
9/19/25
|
From
$6,739
|
34-night Pacific Passage & Japan's Fall Foliage Cruise
Vancouver to Kyoto (Kobe) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Quest
|
Departs
9/19/25
|
From
$11,919
|
11-night Hawaii Cruise
Vancouver to Honolulu |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Solstice
|
Departs
9/21/25
|
From
$1,293
|
23-night Panama Canal & Pacific Coast Cruise
Vancouver to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Caribbean Princess
|
Departs
9/23/25
|
Call For Pricing
|
56-night Tales Of The South Pacific Cruise
Vancouver to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Zaandam
|
Departs
9/24/25
|
Call For Pricing
|
13-night Mexican Riviera & Pacific Coast Cruise
Vancouver to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
9/28/25
|
From
$994
|
20-night Mexican Riviera, California And Pacific Coast Cruise
Vancouver to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
9/28/25
|
From
$2,799
|
21-night Circle Hawaii & California Retreat Cruise
Vancover to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Koningsdam
|
Departs
10/4/25
|
From
$3,204
|
21-night Panama Canal Cruise
Vancover to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/5/25
|
From
$3,499
|
23-night Panama Canal & Pacific Coast Cruise
Vancouver to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Coral Princess
|
Departs
10/21/25
|
Call For Pricing
|
19-night Falklands, South Georgia and Antarctica: Explorers and Kings Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ocean Explorer
|
Departs
11/4/24
|
Call For Pricing
|
10-night Antarctic Explorer – Discovering the 7th Continent Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
World Explorer
|
Departs
11/5/24
|
Call For Pricing
|
10-night Antarctic Explorer – Discovering the 7th Continent Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
World Explorer
|
Departs
11/14/24
|
Call For Pricing
|
9-night Antarctica Direct: Sail and Fly the Drake Passage Cruise/Land Package
Ushuaia to Puerto Natales, Chile |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
11/19/24
|
From
$11,061
|
10-night Antarctic Explorer: Discovering the 7th Continent Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ocean Explorer
|
Departs
11/22/24
|
Call For Pricing
|
10-night Antarctic Explorer – Discovering the 7th Continent Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
World Explorer
|
Departs
11/23/24
|
Call For Pricing
|
10-night Antarctic Explorer: Discovering the 7th Continent Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ocean Explorer
|
Departs
12/1/24
|
Call For Pricing
|
9-night Antarctica Direct: Sail and Fly the Drake Passage Cruise/Land Package
Ushuaia to Puerto Natales, Chile |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
12/8/24
|
From
$11,174
|
10-night Antarctic Explorer: Discovering the 7th Continent Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ocean Explorer
|
Departs
12/10/24
|
Call For Pricing
|
19-night Falklands, South Georgia and Antarctica: Explorers and Kings Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ocean Explorer
|
Departs
12/19/24
|
Call For Pricing
|
9-night Antarctica Direct: Sail and Fly the Drake Passage Cruise/Land Package
Ushuaia to Puerto Natales, Chile |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
12/27/24
|
From
$13,081
|