Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,937 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
7-night Costa Rica To Panama Cruise
Puerto Caldera (Puntarenas) to Balboa |
Cruise Line
Star Clippers
|
Cruise Ship
Star Clipper
|
Departs
12/27/25
|
Call For Pricing
|
123-night World Cruise 2025: Ft. Lauderdale to Barcelona
Ft. Lauderdale to Barcelona |
Cruise Line
Crystal Cruises
|
Cruise Ship
Crystal Serenity
|
Departs
1/7/25
|
From
$66,500
|
63-night Patagonia to Iberia Mosaic Voyage
Santiago (San Antonio) to Barcelona |
Cruise Line
Oceania Cruises
|
Cruise Ship
Marina
|
Departs
3/6/25
|
From
$16,599
|
42-night Grand Voyage: Pole To Pole
Buenos Aires to Barcelona |
Cruise Line
Holland America Line
|
Cruise Ship
Volendam
|
Departs
3/13/25
|
Call For Pricing
|
45-night Brilliant Brazil & Iberia Voyage
Buenos Aires to Barcelona |
Cruise Line
Oceania Cruises
|
Cruise Ship
Marina
|
Departs
3/24/25
|
From
$15,499
|
21-night Southern Atlantic Crossing Cruise
Buenos Aires to Barcelona |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Jupiter (Ocean)
|
Departs
3/24/25
|
From
$5,599
|
33-night Samba & Flamenco Rhythms Voyage
Rio de Janeiro to Barcelona |
Cruise Line
Oceania Cruises
|
Cruise Ship
Marina
|
Departs
4/5/25
|
From
$11,299
|
155-night Azamara World Voyage
Miami to Barcelona |
Cruise Line
Azamara
|
Cruise Ship
Azamara Onward
|
Departs
1/6/26
|
From
$41,000
|
21-night Southern Atlantic Crossing Cruise
Buenos Aires to Barcelona |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Jupiter (Ocean)
|
Departs
3/11/26
|
From
$5,499
|
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise Cruise/Land Package
Medellin to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
1/13/25
|
Call For Pricing
|
7-night Wonders of Colombia with 2 Nights Cartagena Pre-Cruise Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
1/16/25
|
Call For Pricing
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
1/18/25
|
Call For Pricing
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/1/25
|
Call For Pricing
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/10/25
|
Call For Pricing
|
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/13/25
|
Call For Pricing
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/15/25
|
Call For Pricing
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/24/25
|
Call For Pricing
|
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/27/25
|
Call For Pricing
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/1/25
|
Call For Pricing
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/15/25
|
Call For Pricing
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/24/25
|
From
$6,024
|
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/27/25
|
From
$4,599
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/29/25
|
From
$3,699
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/7/25
|
Call For Pricing
|