Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,937 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

7-night Costa Rica To Panama Cruise

Puerto Caldera (Puntarenas) to Balboa

Cruise Line
Star Clippers
Cruise Ship
Star Clipper
Departs
12/27/25
 
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123-night World Cruise 2025: Ft. Lauderdale to Barcelona

Ft. Lauderdale to Barcelona

Cruise Line
Crystal Cruises
Cruise Ship
Crystal Serenity
Departs
1/7/25
From
$66,500
63-night Patagonia to Iberia Mosaic Voyage

Santiago (San Antonio) to Barcelona

Cruise Line
Oceania Cruises
Cruise Ship
Marina
Departs
3/6/25
From
$16,599
42-night Grand Voyage: Pole To Pole

Buenos Aires to Barcelona

Cruise Line
Holland America Line
Cruise Ship
Volendam
Departs
3/13/25
 
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45-night Brilliant Brazil & Iberia Voyage

Buenos Aires to Barcelona

Cruise Line
Oceania Cruises
Cruise Ship
Marina
Departs
3/24/25
From
$15,499
21-night Southern Atlantic Crossing Cruise

Buenos Aires to Barcelona

Cruise Line
Viking Cruises
Cruise Ship
Viking Jupiter (Ocean)
Departs
3/24/25
From
$5,599
33-night Samba & Flamenco Rhythms Voyage

Rio de Janeiro to Barcelona

Cruise Line
Oceania Cruises
Cruise Ship
Marina
Departs
4/5/25
From
$11,299
155-night Azamara World Voyage

Miami to Barcelona

Cruise Line
Azamara
Cruise Ship
Azamara Onward
Departs
1/6/26
From
$41,000
21-night Southern Atlantic Crossing Cruise

Buenos Aires to Barcelona

Cruise Line
Viking Cruises
Cruise Ship
Viking Jupiter (Ocean)
Departs
3/11/26
From
$5,499
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise Cruise/Land Package

Medellin to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
1/13/25
 
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7-night Wonders of Colombia with 2 Nights Cartagena Pre-Cruise Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
1/16/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
1/18/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/1/25
 
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12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/10/25
 
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9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/13/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/15/25
 
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12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/24/25
 
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9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/27/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
3/1/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
3/15/25
 
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12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
3/24/25
From
$6,024
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
3/27/25
From
$4,599
7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
3/29/25
From
$3,699
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
4/7/25
 
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