Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,912 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
7-night Panama Canal, Cartagena, San Blas Islands, and More Cruise
Fuerte Amador to Oranjestad, Aruba |
Cruise Line
Windstar Cruises
|
Cruise Ship
Star Pride
|
Departs
3/8/25
|
From
$2,599
|
14-night Panama to Antigua Cruise
Balboa to St. John's |
Cruise Line
Star Clippers
|
Cruise Ship
Star Clipper
|
Departs
3/22/25
|
Call For Pricing
|
14-night Panama To Antigua Cruise
Balboa to St. John's Antigua |
Cruise Line
Star Clippers
|
Cruise Ship
Royal Clipper
|
Departs
11/15/25
|
Call For Pricing
|
7-night Panama To Costa Rica Cruise
Balboa to Puerto Caldera (Puntarenas) |
Cruise Line
Star Clippers
|
Cruise Ship
Star Clipper
|
Departs
12/13/25
|
Call For Pricing
|
14-night Panama To Jamaica Cruise
Balboa to Montego Bay |
Cruise Line
Star Clippers
|
Cruise Ship
Star Clipper
|
Departs
1/3/26
|
Call For Pricing
|
21-night Southern Atlantic Crossing Cruise
Barcelona to Buenos Aires |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Jupiter (Ocean)
|
Departs
10/18/24
|
From
$5,599
|
21-night Southern Atlantic Crossing Cruise
Barcelona to Buenos Aires |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Jupiter (Ocean)
|
Departs
11/8/25
|
From
$5,499
|
16-night Trans-Atlantic Cruise
Barcelona to Punta Cana |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Sky
|
Departs
12/6/25
|
From
$1,229
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
1/25/25
|
Call For Pricing
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
1/25/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/8/25
|
Call For Pricing
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/8/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/22/25
|
Call For Pricing
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
2/22/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/8/25
|
Call For Pricing
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/8/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/22/25
|
Call For Pricing
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
3/22/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/5/25
|
Call For Pricing
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/5/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/19/25
|
From
$3,599
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/19/25
|
Call For Pricing
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/3/25
|
From
$3,349
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/3/25
|
Call For Pricing
|